Nicotine inhibits the VTA to Amygdala dopamine pathway to promote anxiety.
Claire Nguyen, Sarah Mondoloni, Tinaïg Le Borgne, Ines Centeno, Maxime Come, Joachim Jehl, Clément Solié, Lauren M Reynolds, Romain Durand-de Cuttoli, Stefania Tolu, Sébastien Valverde, Steve Didienne, Bernadette Hannesse, Jean-François Fiancette, Stéphanie Pons, Uwe Maskos, Véronique Deroche-Gamonet, Deniz Dalkara, Jean-Pierre Hardelin, Alexandre Mourot, Fabio Marti, Philippe Faure
Neuron 2021 doi :10.1016/j.neuron.2021.06.013 Access PDF>


Adolescent dopamine development: connecting experience with vulnerability or resilience to psychiatric disease
Lauren M Reynolds, Cecilia Flores
In : Diagnosis and Management of Neurodevelopmental Disorders: The Neuroscience of Development 2021 Academic Press, ISBN 9780128179888. doi: 10.1016/B978-0-12-817988-8.00026-9 PDF>




Dopamine Axon Targeting in the Nucleus Accumbens in Adolescence Requires Netrin-1
Santiago Cuesta,Dominique Nouel, Lauren M Reynolds, Alice Morgunova, Angélica Torres-Berrío, Amanda White, Giovanni Hernandez, Helen M Cooper, Cecilia Flores
Frontiers in Cell and Developmental Biology 2020 8:487 doi: 10.3389/fcell.2020.00487 PDF>


DCC-dependent developmental effects of abused- versus therapeutic-like amphetamine doses in adolescence 
Santiago Cuesta, Jose Maria Restrepo-Lozano, Christina Popescu, Susan He, Lauren M Reynolds, Sonia Israel, Giovanni Hernandez, Rana Rais, Barbara S Slusher, Cecilia Flores
Addiction Biology 2020 25(4):e12791 doi: 10.1111/adb.12791 PDF>




Early adolescence is a critical period for the maturation of inhibitory behavior
Lauren M Reynolds,Leora Yetnikoff, Matthew Pokinko, Michael Wodzinski, Julia G Epelbaum, Laura C Lambert, Marie-Pierre Cossette, Andreas Arvanitogiannis, Cecilia Flores
Cerebral Cortex 2019 29(9):3676-3686 doi: 10.1093/cercor/bhy247 PDF>


Guidance Cues: Linking Drug Use in Adolescence with Addiction Vulnerability
Lauren M Reynolds, Cecilia Flores
Neuropsychopharmacology 2019 doi: 10.1038/s41386-018-0221-7 PDF>




Non-contingent exposure to amphetamine in adolescence recruits miR-218 to regulate Dcc expression in the VTA
Santiago Cuesta, Jose Maria Restrepo-Lozano, Steven Silvestrin, Daniel Hoops, Dominique Nouel, Angélica Torres-Berrío, Lauren M Reynolds, Andreas Arvanitiogiannis, Cecilia Flores
Neuropsychopharmacology 2018 43(4), 900–911 doi: 10.1038/npp.2017.284 PDF >


Featured in NIDA Notes


DCC receptors drive prefrontal cortex maturation by determining dopamine axon targeting in adolescence
Lauren M Reynolds, Matthew Pokinko, Angélica Torres-Berrío, Santiago Cuesta, Laura C Lambert, Michael Wodzinski, Esther Del Cid-Pellitero, Colleen Manitt, Paul Krimpenfort, Bryan Kolb, Cecilia Flores 
Biological Psychiatry 2018 83(2): 181–192 doi: 10.1016/j.biopsych.2017.06.009  PDF >



Featured in LaPress (Français)


Featured in NIDA News


Dopamine development to the orbital prefrontal cortex is protracted and sensitive to amphetamine in adolescence
Daniel Hoops, Lauren M Reynolds, Jose Maria Restrepo-Lozano, Cecilia Flores
eNeuro 2018 doi: 10.1523/ENEURO.0372-17.2017 PDF >




Advances in understanding and treating mental illness: Proceedings of the 40th Canadian College of Neuropsychopharmacology Annual Meeting Symposia
Catherine P Normandeau†, Darya Naumova†, Shawna L Thompson†, Mohammed Ebrahimzadeh†, Yu Qing Liu†, Lauren Reynolds†, Hong-Yang Ren, Emily R Hawken, Éric C Dumont
Journal of Psychiatry and Neuroscience
2017 Sep;42(5):353-358 doi: 10.1503.jpn/170120   PDF >  
† these authors contributed equally to this work


A non-invasive restraining system for awake mouse imaging
Dan Madularu, Axel P Mathieu, Chathura Kumaragamage, Lauren M Reynolds, Jamie Near, Cecilia Flores, M. Natasha Rajah
Journal of Neuroscience Methods 2017 287, 53–57. doi: 10.1016/j.jneumeth.2017.06.008 PDF > 




dcc haploinsufficiency results in blunted sensitivity to cocaine enhancement of reward seeking
Lauren M Reynolds, Anthony J Gifuni, E. Tess McCrea, Peter Shizgal, Cecilia Flores
Behavioural Brain Research 2016 298A: 27-31 doi: 10.1016/j.bbr.2015.05.020 PDF >
* Invited Submission to Special Issue: Developmental Regulation of Memory in Anxiety and Addiction.




Amphetamine in adolescence disrupts the development of medial prefrontal cortex dopamine connectivity in a dcc-dependent manner
Lauren M Reynolds, Carolina S Makowski, Sandra V Yogendran, Silke Kiessling, Nicolas Cermakian, Cecilia Flores
Neuropsychopharmacology 2015 Mar;13(40):1101-12 doi: 10.1038/npp.2014.287  PDF > 




Neural basis of benzodiazepine reward: Requirement for α2-containing GABAA receptors in the nucleus accumbens
Elif Engin, Konstantin I Bakhurin, Kiersten S Smith, Rochelle M Hines, Lauren M Reynolds, W Wannan Tang, Rolf Sprengel, Stephen J Moss, Uwe Rudolph
Neuropsychopharmacology 2014 Jul;39(8):1805-15.  doi: 10.1038/npp.2014.41 PDF > 




Differential roles of GABAA receptor subtypes in benzodiazepine-induced enhancement of brain-stimulation reward
Lauren M Reynolds, Elif Engin, Gabriella Tantillo, Hew Mun Lau, John W Muschamp, William A Carlezon Jr, Uwe Rudolph . (2012).
Neuropsychopharmacology Oct;37(11):2531-40. doi: 10.1038/npp.2012.115 PDF > 



See them in Pubmed!